SYNTHESIS: A solution was made of 12.1 g
N,N,N',N'-tetramethylethylenediamine and 13.8 g of
1,3-dimethoxybenzene in 200 mL 30-60 °C petroleum ether. This was
stirred vigorously under a He atmosphere and cooled to 0 °C with an
external ice bath. There was added 66 mL of 1.6 M butyl lithium in
hexane which produced a white granular precipitate. The reaction
mixture was brought up to room temperature for a few minutes, and then
cooled again to 0 °C. There was then added 18.7 g of di-(n)-butyl
disulfide (this reagent was quite yellow, but was used without any
purification) which changed the granular precipitate to a strange
salmon color. Stirring was continued while the reaction mixture was
brought up to room temperature and finally up to reflux. The reaction
mixture was then added to 600 mL of dilute H2SO4. The two phases were
separated, and the aqueous phase extracted with 2x75 mL Et2O. The
organic phases were combined and the solvent removed under vacuum.
The residue weighed 33.0 g and was a dark yellow oil. Efforts to
remove this color by reductive extraction of a CH2Cl2 solution with
aqueous sodium hydrosulfite were futile. The residue was distilled at
0.3 mm/Hg to give two fractions. The first boiled at 95-115 °C,
weighed 4.1 g and was largely recovered dibutyl disulfide. The
product 2-(n)-butylthio-1,3-dimethoxybenzene boiled at 115-135 °C and
weighed 19.5 g. It was a pale amber oil that could not be induced to
crystallize. Anal. (C12H18O2S) C,H.
To a stirred solution of 19.5 g of
2-(n)-butylthio-1,3-dimethoxybenzene in 75 mL CH2Cl2 there was added
14.5 g elemental bromine dissolved in 75 mL CH2Cl2. The evolution of
HBr was evident, but the reaction was not exothermic. The reaction
was allowed to stir for 1 h and then heated briefly to a reflux on the
steam bath. It was then washed with H2O containing sodium
hydrosulfite which discharged the residual color. After washing with
saturated brine, the solvent was removed under vacuum leaving 26.0 g
of a pale amber oil. This was distilled at 120-140 °C at 0.4 mm/Hg
yielding 4-bromo-2-(n)-butylthio-1,3-dimethoxybenzene as a
yellow-orange oil. It could not be crystallized. Anal. (C12H17BrO2S)
C,H.
To a solution of 11.5 mL diisopropylamine in 50 mL hexane that was
stirred under N2 there was added 50 mL of 1.6 M butyllithium. After
15 min stirring, the reaction mixture became very viscous, and it was
diluted with 150 mL anhydrous THF. After cooling in an ice bath there
was added 2.0 mL CH3CN followed in 1 min with 6.0 g of
4-bromo-2-(n)-butylthio-1,3-dimethoxyanisole a bit at a time over the
course of 1 min. There was the immediate formation of a deep red
color. After stirring for 0.5 h, the mixture was poured into dilute
H2SO4. The organic layer was separated, and the aqueous layer
extracted with 3x75 mL CH2Cl2. These extracts were pooled, dried with
anhydrous K2CO3, and the solvent was removed under vacuum. The
residue was distilled at 0.25 mm/Hg and yielded two fractions. The
first fraction boiled at 125-145 °C, weighed 0.8 g and was discarded.
The second fraction came over at 145-175 °C as a light yellow oil and
weighed 2.2 g. This product,
4-(n)-butylthio-3,5-dimethoxyphenylacetonitrile, was reduced as such
without further purification or analysis.
A solution of LAH under N2 (20 mL of a 1 M solution in anhydrous THF)
was cooled to 0 °C and vigorously stirred. There was added, dropwise,
0.53 mL 100% H2SO4, followed by 2.0 g
4-(n)-butylthio-3,5-dimethoxyphenylacetonitrile in 10 mL anhydrous
THF. The reaction mixture was stirred at 0 °C for a few min, then
brought to room temperature for 1 h, and finally to a reflux for 1 h
on the steam bath. After cooling back to room temperature, there was
added IPA (to destroy the excess hydride) followed by 10% NaOH which
brought the reaction to a basic pH and converted the aluminum oxides
to a loose, white, filterable consistency. These were removed by
filtration, and washed with THF and IPA. The filtrate and washes were
stripped of solvent under vacuum, the residue was suspended in 150 mL
of dilute NaOH and extracted with 3x100 CH2Cl2. These extracts were
pooled and extracted with 2x75 mL diluteH2SO4. Emulsions required
that a considerable additional quantity of H2O be added. The aqueous
phase was made basic, and extracted with 2x100 mL CH2Cl2. After
combining these extracts, the solvent was removed under vacuum
providing a residue that was distilled. The product distilled at
138-168 °C at 0.4 mm/Hg as a white oil weighing 0.7 g. This was
dissolved in a small amount of IPA, neutralized with concentrated HCl
and, with continuous stirring, diluted with several volumes of
anhydrous Et2O. After filtering, Et2O washing, and air drying,
4-(n)-butylthio-3,5-dimethoxyphenethylamine hydrochloride (TB) was
obtained, weighed 0.6 g, and had a mp of 154-155 °C. Anal.
(C14H24ClNO2S) C,H.
DOSAGE: 60 - 120 mg.
DURATION: about 8 h.
QUALITATIVE COMMENTS: (with 35 mg) I was aware of something at about
an hour, and it developed into a benign and beautiful experience which
never quite popped into anything psychedelic. At the fifth hour there
was a distinct drop, and I made what might be thought of as a foolish
effort to rekindle the state with an additional 20 milligrams but it
was too little and too late. There was no regeneration of anything
additional.
(with 60 mg) A very subtle threshold, probably, and six hours into it
there seems to have been little if any effect. My memory of it is not
that certain and now I am not sure that there had been anything at
all.
(with 80 mg) I am vaguely aware of something. The body discomfort
may reflect the use of sardines in tomato sauce for lunch, but still
things are not quite right. Five hours into it I am still in a
wonderful place spiritually, but there seem to be some dark edges. I
might be neurologically sensitive to this.
(with 120 mg) The course of the action of this is extremely clear.
The development was from 5 PM to 7 PM [the experiment started at 4 PM]
and by 10 PM I was dropping and by midnight I went to bed and slept
well. Food was not too interesting, and a glass of wine before
sleeping produced no noticeable effect. This was an uneventful
experience that never really made it off the ground. It was pleasant,
but certainly not psychedelic.
EXTENSIONS AND COMMENTARY: There is a term "dose-dependent" in
pharmacology. When there is a complex action produced by a drug, then
each of the components of this mixture of effects should be expected
to become more intense following a bigger dose of the drug. This is
certainly true with most of the actions of psychoactive drugs.
As to the psychedelic aspects of some drugs, there can be visual
effects, eyes-open (edge-ripples or colors or retinal games) or
eyes-closed (images of the elaborately decorated doors of the mosque,
or of an orchestra floating suspended by its music) or fantasy (you
are moving beyond the confines of your body and invading someone
else's space). The same applies to tactile enhancement, to the
anaesthetic component, to the depth of insight realized from a drug.
The more the drug, as a rule, the more the effect, up to the point
that new and disruptive effects are realized. This latter is called
toxicity.
As to the stimulant component, the same is true. The person gets
wired up, and there is no sleep because there is no hiding from a
cascade of images and meanings, and the body lies there unwilling to
yield guard since both the pounding heart and the interpretive psyche
are demanding attention. These aspects also intensify with
increasingly higher doses.
But an exception to this is the euphoria-producing aspect of a drug.
One sees with increasing doses a continuing "threshold" that makes you
aware, that fluffs the senses, but which seems not, at any level, to
take over or to command the ship. It is truly a catalytic on or off.
You are or you are not. In the "Tomso" effect, this action is
produced by alcohol. There is disinhibition with alcohol which allows
a central intoxication from the drug TOMSO regardless of the amount of
drug used (see under TOMSO). One sees again, here with TB, the case
of a perpetual series of "thresholds." Never the psychedelic or the
stimulant action that increases with increased dose. Always the
simple and ephemeral catalyst of euphoria without substance and
without body. It is a compound that can never be pinned and labeled
in the butterfly collection since it defies an accepted
classification.
This action was seen first with the compound called ARIADNE and when
it was called an anti-depressant, it proved to be commercially
interesting. It is fully possible that TB would be of value to
certain depressed people in exactly the same way.
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