SYNTHESIS: To a well-stirred solution of 6.08 g
2,5-dimethoxy-4-(s)-butylthio-beta-nitrostyrene (see under 2C-T-17 for
its preparation) in 80 mL anhydrous THF under a He atmosphere, there
was added 3.5 mL 10 M borane dimethylsulfide complex, followed by 0.5
g of sodium borohydride. As the stirring continued, the slightly
exothermic reaction slowly faded from bright yellow to pale yellow,
and eventually (after three days stirring) it was substantially
colorless. There was then added 80 mL of 3 N HCl and the mixture
heated on the steam bath for 1 h, and then allowed to return to room
temperature. An additional 600 mL H2O was added (there was a
combination of crystals and globby chunks in the aqueous phase) and
this was then extracted with 3x75 mL CH2Cl2. The color went
completely into the organic phase. This was washed with 2x50 mL
aqueous K2CO3, yielding a rusty-red colored CH2Cl2 solution, which on
removal of the solvent, yielded 4.5 g of a red oil. A side effort to
make the sulfate salt at this stage with H2O and a little H2SO4,
indeed gave solids, but all of the color remained in the sulfate salt.
The red oil was dissolved in 45 mL IPA and neutralized with
concentrated HCl to bright red, not yellow, on universal pH paper.
The addition of 350 mL anhydrous Et2O instituted the slow
precipitation of white crystals. After filtering and air drying,
there was obtained 1.32 g
2,5-dimethoxy-4-(s)-butylthio-N-hydroxyphenethylamine hydrochloride
(HOT-17). The aqueous phase from above was just neutralized with 25%
NaOH (cloudy, slightly pink color) and then made basic with K2CO3 (the
color becomes green). This was extracted with 3x75 mL CH2Cl2, the
extracts pooled, and the solvent removed to yield 0.5 g of a white
oil. This was dissolved in 5 mL IPA, neutralized with concentrated
HCl, and diluted with a equal volume of Et2O. An additional 0.36 g of
product was thus obtained.
DOSAGE: 70 - 120 mg.
DURATION : 12 - 18 h.
QUALITATIVE COMMENTS: (with 70 mg) There was a light feeling, a
little off-the-ground feeling, which made walking about a most
pleasant experience. No distortion of the senses. And there was no
sense of the beginning of a drop of any kind until about the eighth
hour. Sleeping was a bit tricky but it worked out OK (at the twelfth
hour of the experience). A completely valid ++.
(with 120 mg) HOT-17 has an unbelievably GRIM taste--not bitter, but
simply evil. There is a steady and inexorable climb for three hours
to a sound and rolling plus three. There was absolutely no body
difficulty, but there was still something going on upstairs well into
the next day. Writing was surprisingly easy; I was completely content
with the day, and would be interested in exploring it under a variety
of circumstances.
(with 120 mg) This is my first time with this material. It is 4:45
PM. Small nudge at 30 minutes, but not too real. At one hour,
threshold, quite real. 6:15 to a +1. By 7:25, +3 about. 7:45, no
doubt +3. Possibly still climbing; I hope so. No body discomfort at
all, no apparent body push. This aspect of it is similar to the easy
body of the HOT-2. However, it's at times like these that I reflect
on just exactly how hard-headed we two are. I mean, +3 is no longer
the out-of-body, nearly loss of center state it used to be, four years
ago. The question intrudes: would a novice experience this as a very
scary, ego-disintegrating kind of experiment, or not? Silly question
which answers itself. Yes, of course. At 3 hours, aware of some mild
time-distortion. More a tendency to not think in terms of clock-time,
than actual distortion. The mind lazy when attempting to keep track
of clock time. Feel it would be quite easy and pleasant to continue
writing. The energy could very well go in that direction. However,
the idea of the erotic is also quite agreeable. This is, so far, a
good-humored Buddha area of the self.
EXTENSIONS AND COMMENTARY: Two virtues sought by some users of
psychedelic drugs are high intensity and brief action. They want a
quicky. Something that is really effective for a short period of
time, then lets you quickly return to baseline, and presumably back to
the real world out there.
Intensity is often (but not always) regulated by dose. The
pharmacological property of dose-dependency applies to many of these
drugs, in that the more you take, the more you get. If you want more
intensity, take a second pill. And often, you get a longer duration
as an added property. But it is instructive to inquire into the
rationale that promotes brevity as a virtue. I believe that it says
something concerning the reasons for using a psychedelic drug. A
trade off between learning and entertainment. Or between the
achieving of something and the appearance of achieving something. Or,
in the concepts of the classics, between substance and image.
In a word, many people truly believe that they cannot afford the time
or energy required for a deep search into themselves. One has to make
a living, one has to maintain a social life, one has a multitude of
obligations that truly consume the oh-so-few hours in the day. I
simply cannot afford to take a day off just to indulge myself in
such-and-such (choose one: digging to the bottom of a complex concept,
giving my energies to those whom I can help, to search out my inner
strengths and weaknesses) so instead I shall simply do such-and-such
(choose one: read the book review, go to church on Sunday morning, use
a short-acting psychedelic). The world is too much with us. This may
be a bit harsh, but there is some merit to it.
HOT-17 is by no means a particularly potent compound. The hundred
milligram area actually has been the kiss of death to several
materials, as it is often at these levels that some physical concerns
become evident. And it certainly is not a short lived compound. But,
as has been so often the case, the long lived materials have proven to
be the most memorable, in that once the entertainment aspect of the
experience is past you, there is time for dipping deeply into the rich
areas of the thought process, and the working through of ideas and
concepts that are easily available. And when this access is coupled
to the capability of talking and writing, then a rewarding experience
is often the result.
As with the parent compound, 2C-T-17 itself, the presence of an
asym-metric carbon atom out there on the (s)-butyl side chain will
allow the separation of HOT-17 into two components which will be
different and distinct in their actions. The activity of the racemic
mixture often is an amalgamation of both sets of properties, and the
separate assay of each component can often result in a fascinating and
unexpected fractionation of these properties.
Back]
]